Catalytic Osmylation and Antiviral Activity of Some Garbocyclic 5-Substituted Uridine and Cytidine Analogues

Anne Popescu Organic Chemistry 1, Chemical Center, Box 124, S-221 00, Lund, Sweden

Anna-Britta Hörnfeldt Organic Chemistry 1, Chemical Center, Box 124, S-221 00, Lund, Sweden

Salo Gronowitz Organic Chemistry 1, Chemical Center, Box 124, S-221 00, Lund, Sweden

Nils Gunnar Johansson Medivir AB, Lunastigen 7, S-141 44, Huddinge, Sweden

Abstract

Some carbocyclic uridines and cytidines have been dihydroxylated in an osmium catalyzed reaction. Besides the nucleoside analogues, the anti forms, the diastereomeric syn forms were formed. These could be separated and tested with regard to antiviral activity.

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Catalytic Osmylation and Antiviral Activity of Some Garbocyclic 5-Substituted Uridine and Cytidine Analogues

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Catalytic Osmylation and Antiviral Activity of Some Garbocyclic 5-Substituted Uridine and Cytidine Analogues

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