Synthesis of New Thiazolidinone Nucleoside Analogues

J. C. Graciet Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Case 901 13288, Marseille cedex, 9, France; Unité de Recherches INSERM U322, Rétrovirus et Maladies Associées, Campus Universitaire de Luminy, BP 33,13273, Marseille cedex, 9, France

P. Faury Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Case 901 13288, Marseille cedex, 9, France; Unité de Recherches INSERM U322, Rétrovirus et Maladies Associées, Campus Universitaire de Luminy, BP 33,13273, Marseille cedex, 9, France

M. Camplo Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Case 901 13288, Marseille cedex, 9, France; Unité de Recherches INSERM U322, Rétrovirus et Maladies Associées, Campus Universitaire de Luminy, BP 33,13273, Marseille cedex, 9, France

A. S. Charvet Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Case 901 13288, Marseille cedex, 9, France; Unité de Recherches INSERM U322, Rétrovirus et Maladies Associées, Campus Universitaire de Luminy, BP 33,13273, Marseille cedex, 9, France

N. Mourier Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Case 901 13288, Marseille cedex, 9, France; Unité de Recherches INSERM U322, Rétrovirus et Maladies Associées, Campus Universitaire de Luminy, BP 33,13273, Marseille cedex, 9, France

C. Trabaud Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Case 901 13288, Marseille cedex, 9, France; Unité de Recherches INSERM U322, Rétrovirus et Maladies Associées, Campus Universitaire de Luminy, BP 33,13273, Marseille cedex, 9, France

V. Niddam Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Case 901 13288, Marseille cedex, 9, France; Unité de Recherches INSERM U322, Rétrovirus et Maladies Associées, Campus Universitaire de Luminy, BP 33,13273, Marseille cedex, 9, France

V. Simon Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Case 901 13288, Marseille cedex, 9, France; Unité de Recherches INSERM U322, Rétrovirus et Maladies Associées, Campus Universitaire de Luminy, BP 33,13273, Marseille cedex, 9, France

J. L. Kraus Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Case 901 13288, Marseille cedex, 9, France; Unité de Recherches INSERM U322, Rétrovirus et Maladies Associées, Campus Universitaire de Luminy, BP 33,13273, Marseille cedex, 9, France

show all

Abstract

The synthesis of new thiazolididone nucleoside analogues is described. Among the different proposed synthetic pathways, the condensation of various nucleic bases using TMSOTf and Et₃N as coupling reagents on a key sulfoxide thiazolidinone intermediate led to the desired compounds in a one-pot procedure. Analytical data and NMR studies confirmed the proposed structure assignment for these compounds.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Synthesis of New Thiazolidinone Nucleoside Analogues

Information for

Open access

Opportunities

Help and information

Synthesis of New Thiazolidinone Nucleoside Analogues

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature