Synthesis of a Carboxamide Linked T∗T Dimer with an Acyclic Nucleoside Unit and Its Incorporation in Oligodeoxynucleotides

Erik Larsen Department of Chemistry, Odense University, DK-5230, Odense M, Denmark

Krzysztof Danel Department of Chemistry, Odense University, DK-5230, Odense M, Denmark

Erik B. Pedersen Department of Chemistry, Odense University, DK-5230, Odense M, Denmark

Abstract

A T∗T dimer with ∗ representing a 2′-OCH₂CH₂NHC(O)-4′ linkage connecting two nucleoside units was prepared by condensation of (S)-1-[2-(2-aminoethoxy)-3-(4,4′-dimethoxytrityloxy)propyl]thymine with 1,2-dideoxy-1-thyminyl-β-D-erythro-pento-furanuronic acid. The T∗T dimer was incorporated in oligodeoxynucleotides and investigated for hybridization to DNA.

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Synthesis of a Carboxamide Linked T∗T Dimer with an Acyclic Nucleoside Unit and Its Incorporation in Oligodeoxynucleotides

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Synthesis of a Carboxamide Linked T∗T Dimer with an Acyclic Nucleoside Unit and Its Incorporation in Oligodeoxynucleotides

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