Synthesis of the β-2′,3′-Unsaturated Pentopyranosyl Nucleosides and Their 3′-Hydroxymethyl Congeners

Abstract

Fusion of the glycal 3 and purines/pyrimidines without acid catalyst provides anomeric mixtures of the 2′,3′-unsaturated pentopyranosyl nucleosides 4, which have been worked out to furnish the 3′-hydroxymethyl analogues, e.g. 5.