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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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I. NUCLEOSIDES: Chemistry

The Synthesis of Novel Transition State Analogues Related to Imidazole and Purine Nucleotides Involved in the De novo Biosynthesis of Purines

A. Scott Frame Department of Chemistry, Heriot-Watt University, Edinburgh, EH14 4AS, UK.
,
Richard H. Wightman Department of Chemistry, Heriot-Watt University, Edinburgh, EH14 4AS, UK.
&
G. Mackenzie School of Chemistry, University of Hull, Hull, HU6 7RX, UK.
Pages 363-366 | Published online: 16 Feb 2007
 
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Abstract

5-Amino-4-sulphonamidoimidazole ribofuranosyl nucleosides and a related imidazothiadiazine dioxide nucleoside have been synthesized as potential inhibitors of enzymes involved in the de novo biosynthesis of purine nucleotides.

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