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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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I. NUCLEOSIDES: Chemistry

Synthesis of Sugar Modified Nucleosides Containing Nicotinic, Quinaldic, Indol-3-ylpropionic or 1-Nitroanthraquinone-2-carboxylic Acid Residue

S. Ya. Melnik Cancer Research Center of the Russian Academy of Medical Sciences, 115478, Moscow, Russia
,
L. V. Ektova Cancer Research Center of the Russian Academy of Medical Sciences, 115478, Moscow, Russia
,
O. V. Goryunova Cancer Research Center of the Russian Academy of Medical Sciences, 115478, Moscow, Russia
,
E. V. Khorysheva Cancer Research Center of the Russian Academy of Medical Sciences, 115478, Moscow, Russia
,
S. V. Makutova Cancer Research Center of the Russian Academy of Medical Sciences, 115478, Moscow, Russia
,
I. L. Plikhtyak Cancer Research Center of the Russian Academy of Medical Sciences, 115478, Moscow, Russia
&
I. V. Yartseva Cancer Research Center of the Russian Academy of Medical Sciences, 115478, Moscow, Russia
 show all
Pages 377-380 | Published online: 16 Feb 2007
 
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Abstract

The nucleoside derivatives were synthesized with arylcarbonic acid residue as an anchor group at the sugar moiety coupled by an ester or an amide bond. Their cytotoxic properties and effects on DNA structure were studied.

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