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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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I. NUCLEOSIDES: Chemistry

Base-Transposed Chiral Isomeric Nucleosides

Vasu Nair Department of Chemistry, University of Iowa, Iowa City, Iowa, 52242, U.S.A.
,
Lawrence B. Zintek Department of Chemistry, University of Iowa, Iowa City, Iowa, 52242, U.S.A.
,
Pascal J. Bolon Department of Chemistry, University of Iowa, Iowa City, Iowa, 52242, U.S.A.
&
Todd B. Sells Department of Chemistry, University of Iowa, Iowa City, Iowa, 52242, U.S.A.
Pages 385-388 | Published online: 16 Feb 2007
 
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Abstract

The synthesis and anti-HIV activities of a number of new analogues of basetransposed chiral isomeric nucleosides are described. Modifications of the anti-HIV active compound, (S,S)-isodideoxyadenosine, included both the base and carbohydrate regions.

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