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Nucleosides and Nucleotides
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Volume 14, Issue 3-5
Synthesis of 3′-Amino-3′-deoxyadenosine ....

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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5

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I. NUCLEOSIDES: Chemistry

Synthesis of 3′-Amino-3′-deoxyadenosine Derivatives as Potential Drugs for the Treatment of Malaria

Johanna Soenens Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Universiteit Gent, Harelbekestraat, 72, B-9000, Gent, Belgium

Guido François Laboratory of Protozoology, Prince Leopold Institute of Tropical Medicine, Nationalestraat, 155, B-2000, Antwerpen, Belgium

Elfride Van den Eeckhout Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Universiteit Gent, Harelbekestraat, 72, B-9000, Gent, Belgium

Piet Herdewijn Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Universiteit Gent, Harelbekestraat, 72, B-9000, Gent, Belgium

Pages 409-411 | Published online: 16 Feb 2007

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Abstract

A series of 3′-substituted 3′-amino-3′-deoxyadenosine analogues were synthesized and subsequently tested against the human malaria parasite Plasmodium falciparum in vitro. Several amongst them displayed pronounced antiplasmodial activities.

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