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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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I. NUCLEOSIDES: Biophysics/Biochemistry

Yet Another Mechanism of HIV Reverse Transcriptase Inhibition?

Jean M. J. Tronchet Department of Pharmaceutical Chemistry, Sciences II, University of Geneva, CH-1211, Geneva, 4, (Switzerland)
,
Martina Zséaly Department of Pharmaceutical Chemistry, Sciences II, University of Geneva, CH-1211, Geneva, 4, (Switzerland)
,
Olivier Lassout Department of Pharmaceutical Chemistry, Sciences II, University of Geneva, CH-1211, Geneva, 4, (Switzerland)
,
Martin Grigorov Department of Pharmaceutical Chemistry, Sciences II, University of Geneva, CH-1211, Geneva, 4, (Switzerland)
&
Annie Grouiller Department of Pharmaceutical Chemistry, Sciences II, University of Geneva, CH-1211, Geneva, 4, (Switzerland)
Pages 511-515 | Published online: 16 Feb 2007
 
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Abstract

Bicyclonucleosides like 3 are active against HIV-1 and HIV-2 after phosphorylation. They most probably act as their native bicyclic form fundamentally different, structurally, from that of AZT.

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