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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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I. NUCLEOSIDES: Biological Activity

Synthesis and Antiviral Evaluation of 3′-Substituted Thymidine Analogues Derived from 3′-Amino-3′-deoxythymidine

C. Pannecouque Laboratory of Medicinal Chemistry (F. F. W.), Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat, 10, B-3000, Leuven, Belgium
,
K. Van Poppel Laboratory of Medicinal Chemistry (F. F. W.), Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat, 10, B-3000, Leuven, Belgium
,
J. Balzarini Laboratory of Medicinal Chemistry (F. F. W.), Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat, 10, B-3000, Leuven, Belgium
,
P. Claes Laboratory of Medicinal Chemistry (F. F. W.), Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat, 10, B-3000, Leuven, Belgium
,
E. De Clercq Laboratory of Medicinal Chemistry (F. F. W.), Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat, 10, B-3000, Leuven, Belgium
&
P. Herdewijn Laboratory of Medicinal Chemistry (F. F. W.), Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat, 10, B-3000, Leuven, Belgium
Pages 541-544 | Published online: 16 Feb 2007
 
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Abstract

To assess the structure-activity relationship for antiviral activity, a series of 3′-deoxy-3′-N-functionalized thymidine analogues were synthesized. Several of these thymidine analogues show moderate in vitro activity against HIV-1 and HIV-2.

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