Synthesis and Antiviral Evaluation of 3′-Deoxy-β-L-erythro-pentofuranosyl Nucleosides of the Five Naturally Occurring Nucleic Acid Bases

Abstract

The hitherto unknown title compounds were stereospecifically synthesized by glycosylation of pyrimidine and purine aglycons with a suitably peracylated 3′-deoxy-β-L-erythro-pentofuranose, followed by removal of the protecting groups. All the prepared compounds were tested for their ability to inhibit the replication of a variety of DNA and RNA viruses (including HIV), but they did not show significant antiviral activity.