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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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I. NUCLEOSIDES: Biological Activity

New Prodrugs of 9-(2-Phosphonomethoxyethyl)adenine [PMEA]: Synthesis and Stability Studies

S. Benzaria Laboratoire de Chimie Bio-Organique, U. R. A 488 CNRS, Universitéa de Montpellier II, 34095, Montpellier Céadex, 5
,
G. Gosselin Laboratoire de Chimie Bio-Organique, U. R. A 488 CNRS, Universitéa de Montpellier II, 34095, Montpellier Céadex, 5
,
H. Pelicano Laboratoire de Chimie Bio-Organique, U. R. A 488 CNRS, Universitéa de Montpellier II, 34095, Montpellier Céadex, 5
,
G. Maury Laboratoire de Chimie Bio-Organique, U. R. A 488 CNRS, Universitéa de Montpellier II, 34095, Montpellier Céadex, 5
,
A.-M. Aubertin Universitéa Louis Pasteur, INSERM U 74, 67000, Strasbourg, (France)
,
G. Obert Universitéa Louis Pasteur, INSERM U 74, 67000, Strasbourg, (France)
,
A. Kirn Universitéa Louis Pasteur, INSERM U 74, 67000, Strasbourg, (France)
&
J.-L. Imbach Laboratoire de Chimie Bio-Organique, U. R. A 488 CNRS, Universitéa de Montpellier II, 34095, Montpellier Céadex, 5
 show all
Pages 563-565 | Published online: 16 Feb 2007
 
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Abstract

The synthesis, and stability in different media of new PMEA prodrugs, with S-acylthioethyl (SATE) as enzyme-labile phosphonate protecting groups, are described in comparison with the already known Bis(POM)- and Bis(DTE)PMEA.

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