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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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I. NUCLEOSIDES: Biological Activity

Antiviral Activity of Selected Nucleoside Analogues Against Human Herpes Virus Type 6

D. Reymen Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
,
L. Naesens Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
,
J. Balzarini Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
,
A. Holy Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
&
E. De Clercq Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
Pages 567-570 | Published online: 16 Feb 2007
 
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Abstract

HHV-6 was evaluated in vitro for its susceptibility to a broad range of nucleoside analogues. PFA and several acyclic nucleoside phophonates emerged as the most potent inhibitors of HHV-6 replication as monitored by a newly developed immunofluorescence / flow cytometric assay as well as by microscopical evaluation of their inhibitory effect on HHV-6-induced cytopathogenicity.

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