Hept Derivatives: 6-Benzyl-1-ethoxymethyl-5-isopropyluracil (MKC-442)

Masanori Baba Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, 890

Hlromichi Tanaka Department of Synthetic Chemistry, Showa University, Tokyo, 142

Tadashi Miyasaka Department of Synthetic Chemistry, Showa University, Tokyo, 142

Satoshi Yuasa Mitsubishi Kasei Corporation Research Center, Yokohama, 227, Japan

Masaru Ubasawa Mitsubishi Kasei Corporation Research Center, Yokohama, 227, Japan

Richard T. Walker Department of Chemistry, University of Birmingham, Birmingham, B15 2TT, Great Britain

Erik De Clercq Rega Institute for Medical Reserach, Katholieke Universiteit Leuven, B-3000, Leuven, Belgium

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Abstract

The 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) derivatives have been found to be potent and specific inhibitors of human immunodeficiency virus type 1 (HIV-1) replication in vitro. Among the compounds, MKC-442 (6-benzyl-1-ethoxymethyl-5-isopropyluracil) has recently been chosen as a candidate for clinical efficacy and safety studies in patients with the acquired immune deficiency syndrome (AIDS).

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Hept Derivatives: 6-Benzyl-1-ethoxymethyl-5-isopropyluracil (MKC-442)

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Hept Derivatives: 6-Benzyl-1-ethoxymethyl-5-isopropyluracil (MKC-442)

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