Evidence for the Involvement of the Small Subunit of HIV-1 Reverse Transcriptase (RT) in the TSAO-Resistance

Heidi Jonckheere Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat, 10, B-3000, Leuven, Belgium

Jean-Marc Taymans Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat, 10, B-3000, Leuven, Belgium

Jan Balzarini Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat, 10, B-3000, Leuven, Belgium

Sonsoles Veláazquez Instituto de Quimica Medica (CSIC), Juan de la Cierva 3, E-20006, Spain

Maria Jose Camarasa Instituto de Quimica Medica (CSIC), Juan de la Cierva 3, E-20006, Spain

Jan Desmyter Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat, 10, B-3000, Leuven, Belgium

Erik De Clercq Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat, 10, B-3000, Leuven, Belgium

Jozef Annéa Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat, 10, B-3000, Leuven, Belgium

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Abstract

By introducing the TSAO-resistance mutation 138Glu→Lys in only the p51 subunit of HIV-1 RT, we obtained compelling evidence for a structural and functional role of the p51 subunit in the sensitivity and/or resistance of the enzyme to the TSAO-derivatives.

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Evidence for the Involvement of the Small Subunit of HIV-1 Reverse Transcriptase (RT) in the TSAO-Resistance

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Evidence for the Involvement of the Small Subunit of HIV-1 Reverse Transcriptase (RT) in the TSAO-Resistance

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