Induction of Erythroid Differentiation of Human Leukemia K562 Cells by the Acyclic Nucleoside Phosphonate 9-(2-Phosphonylmethoxyethyl)adenine (PMEA)

S. Hatse Laboratory of Virology and Experimental Chemotherapy, Rega-Institute for Medical Research, Katholieke Universiteit Leuven, Belgium

J. Balzarini Laboratory of Virology and Experimental Chemotherapy, Rega-Institute for Medical Research, Katholieke Universiteit Leuven, Belgium

E. De Clercq Laboratory of Virology and Experimental Chemotherapy, Rega-Institute for Medical Research, Katholieke Universiteit Leuven, Belgium

Abstract

9-(2-Phosphonylmethoxyethyl)adenine (PMEA), the prototype compound of a well-defined structural class of potent and selective anti-retroviral agents, was found to be endowed with long-lasting and dose-dependent differentiation-inducing properties in human erythroleukemia K562 cell cultures.

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Induction of Erythroid Differentiation of Human Leukemia K562 Cells by the Acyclic Nucleoside Phosphonate 9-(2-Phosphonylmethoxyethyl)adenine (PMEA)

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Induction of Erythroid Differentiation of Human Leukemia K562 Cells by the Acyclic Nucleoside Phosphonate 9-(2-Phosphonylmethoxyethyl)adenine (PMEA)

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