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Abstract
In this study the role of methyl-thioIMP (Me-tIMP) formation in 6-mercaptopurine (6MP) cytotoxicity was determined in Molt F4 human malignant T-lymphoblasts. Cytotoxicity of 6MP was increased under conditions where Me-tIMP formation was favored, indicating a role for Me-tIMP in 6MP cytotoxicity. Furthermore, 6MP treatment caused a decrease in concentration of the methyldonor S-adenosylmethionine (S-AdoMet). This could influence many intracellular methylation processes, for example DNA methylation.