An Improved Synthesis of N⁶-(6-Aminohexyl)FAD

Ashty Saleh Laboratorium voor Organische Synthese, K. U. Leuven Celestijnenlaan 200F, B-3001, Leuven-Heverlee, Belgium

Frans Compernolle Laboratorium voor Organische Synthese, K. U. Leuven Celestijnenlaan 200F, B-3001, Leuven-Heverlee, Belgium

Gerard Janssen Rega Instituut, Minderbroedersstraat 10, B-3000, Leuven, Belgium

Abstract

We report an improved synthesis of N ⁶-(6-aminohexyl)FAD (1) using an efficient one-pot conversion of inosine to the N-trifluoroacetyl protected N ⁶-(6-aminohexyl)adenosine 3. The 5′-O-phosphorylated AMP derivative 4, activated as the imidazolide, was coupled with commercial sodium riboflavin phosphate by using 18-crown-6 in DMF.

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An Improved Synthesis of N⁶-(6-Aminohexyl)FAD

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An Improved Synthesis of N6-(6-Aminohexyl)FAD

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An Improved Synthesis of N⁶-(6-Aminohexyl)FAD