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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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II. NUCLEOTIDES: Chemistry

2-Cyanoethyl H-Phosphonate. A Reagent for the Mild Preparation of Nucleoside H-Phosphonate Monoesters

Tomas Szabóa Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91, Stockholm, Sweden
,
Helena Almer Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91, Stockholm, Sweden
,
Roger Ströumberg Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91, Stockholm, Sweden
&
Jacek Stawinski Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91, Stockholm, Sweden
Pages 715-716 | Published online: 16 Feb 2007
 
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Abstract

2-Cyanoethyl H-phosphonate was condensed with protected nucleoside derivatives and the cyanoethyl group subsequently removed by anhydrous base to give the corresponding nucleoside H-phosphonate in good yield.

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