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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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II. NUCLEOTIDES: Biophysics/Biochemistry

Methylene and Halomethylene Analogues of Diadenosine 5′,5″-P1, P3-Triphosphate (ApppA) as Substrates or Inhibitors of ApppA-Degrading Enzymes

Andrzej Guranowski Katedra Biochemii i Biotechnologii, Akademia Rolnicza, ul. Wolyńska, 35, 60-637, Poznań, Poland
,
Elżibieta Starzyńska Katedra Biochemii i Biotechnologii, Akademia Rolnicza, ul. Wolyńska, 35, 60-637, Poznań, Poland
,
Lidia Gzik Katedra Biochemii i Biotechnologii, Akademia Rolnicza, ul. Wolyńska, 35, 60-637, Poznań, Poland
,
Steve P. Langston Departments of Chemistry and Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield, Sheffield, S3 7HF, U.K.
,
Paul Brown Moleatlar Biology and Biotechnoiogv, krebs Institute, University of Sheffield, Sheffield, S3 7HF, U. K
&
G. Michael Blackburn Departments of Chemistry and Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield, Sheffield, S3 7HF, U.K.
Pages 731-734 | Published online: 16 Feb 2007
 
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Abstract

Relative velocities and inhibition constants have been determined for three ApppA-degrading enzymes using six chemically synthesized analogues of ApppA.

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