Qualitative and Quantitative Analysis of Cyclic Nucleotides and Related Enzymes by Static and Dynamic Fast Atom Bombardment Mass Spectrometry

James I. Langridge Biochemistry Group, School of Biological Sciences, and Mass Spectrometry Research Unit Department of Chemistry, University of Wales Swansea, Singleton Park, Swansea, SA2 8PP, United Kingdom

A. Gareth Brenton Biochemistry Group, School of Biological Sciences, and Mass Spectrometry Research Unit Department of Chemistry, University of Wales Swansea, Singleton Park, Swansea, SA2 8PP, United Kingdom

Terry J. Walton Biochemistry Group, School of Biological Sciences, and Mass Spectrometry Research Unit Department of Chemistry, University of Wales Swansea, Singleton Park, Swansea, SA2 8PP, United Kingdom

Frank M. Harris Biochemistry Group, School of Biological Sciences, and Mass Spectrometry Research Unit Department of Chemistry, University of Wales Swansea, Singleton Park, Swansea, SA2 8PP, United Kingdom

Russell P. Newton Biochemistry Group, School of Biological Sciences, and Mass Spectrometry Research Unit Department of Chemistry, University of Wales Swansea, Singleton Park, Swansea, SA2 8PP, United Kingdom

Abstract

Fast atom bombardment mass spectrometry in concert with collisionally-induced dissociation and mass-analysed kinetic energy spectrum scanning has enabled unequivocal identification of putative cyclic nucleotides in tissue extracts; quantitative analyses have enabled kinetic studies of cyclic nucleotide-related enzymes with multi-component monitoring, and dynamic spectrometric systems provide a potential means of continuous assay for these enzymes.

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Qualitative and Quantitative Analysis of Cyclic Nucleotides and Related Enzymes by Static and Dynamic Fast Atom Bombardment Mass Spectrometry

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Qualitative and Quantitative Analysis of Cyclic Nucleotides and Related Enzymes by Static and Dynamic Fast Atom Bombardment Mass Spectrometry

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