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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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II. NUCLEOTIDES: Biological Activity

Synthesis of Nucleotide Lipophilic Prodrugs Containing Two Inhibitors Targeted Against Different Phases of the HIV Replication Cycle

D. Bonnaffé Unité de Chimie Organique, URA CNRS 487, Institut Pasteur 28 rue du Docteur Roux, 75724, Paris Cedex, 15, France; Laboratoire de Chimie Organique Multifonctionnelle, URA CNRS 462, Bat 420 Université, Paris Sud, 91405, Orsay Cedex
,
B. Dupraz Unité de Chimie Organique, URA CNRS 487, Institut Pasteur 28 rue du Docteur Roux, 75724, Paris Cedex, 15, France
,
J. Ughetto-Monfrin Unité de Chimie Organique, URA CNRS 487, Institut Pasteur 28 rue du Docteur Roux, 75724, Paris Cedex, 15, France
,
A. Namane Unité de Chimie Organique, URA CNRS 487, Institut Pasteur 28 rue du Docteur Roux, 75724, Paris Cedex, 15, France
&
T. Huynh Dinh Unité de Chimie Organique, URA CNRS 487, Institut Pasteur 28 rue du Docteur Roux, 75724, Paris Cedex, 15, France
Pages 783-787 | Published online: 16 Feb 2007
 
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Abstract

We describe the preparation of nucleoside acyl 5′-di or 5′-triphosphates, containing a nucleoside analog moiety and 13-oxa-myristic acid as lipophilic chain. At physiological pH these products liberated exclusively the corresponding nucleotides.

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