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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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III. OLIGONUCLEOTIDES: Chemistry

Chemical and Enzymatic Synthesis of 2′-Deoxy-iso-inosine and Its Incorporation into DNA

Jean-Jacques Beaussire Unité de Chimie Organique, URA-CNRS 487, Département de BGM, Institut Pasteur, 28, rue du Dr Roux, 75724, Paris Cedex
&
Sylvie Pochet Unité de Chimie Organique, URA-CNRS 487, Département de BGM, Institut Pasteur, 28, rue du Dr Roux, 75724, Paris Cedex
Pages 805-808 | Published online: 16 Feb 2007
 
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Abstract

Two procedures for the preparation of 2′-deoxy-iso-inosine (1) are presented. Synthesis of 3′-phosphoramidite (7) and 3′-phosphonate (8) derivatives are described, as well as an oligodeoxynucleotide containing iso-I.

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