Peptide Analogues of DNA Consisting of l-α-Amino-γ-thymine Butyric Acid and l-Valine Subunits

G. Ceulemans Rega Institute for Medical Research, Laboratory of Medicinal Chemistry, Faculty of Pharmacy Katholieke Universiteit Leuven, B-3000, Leuven, Belgium

K. Khan Rega Institute for Medical Research, Laboratory of Medicinal Chemistry, Faculty of Pharmacy Katholieke Universiteit Leuven, B-3000, Leuven, Belgium

A. Van Schepdael Rega Institute for Medical Research, Laboratory of Medicinal Chemistry, Faculty of Pharmacy Katholieke Universiteit Leuven, B-3000, Leuven, Belgium

P. Herdewijn Rega Institute for Medical Research, Laboratory of Medicinal Chemistry, Faculty of Pharmacy Katholieke Universiteit Leuven, B-3000, Leuven, Belgium

Abstract

Reaction of N-Boc-L-homoserine benzylester with N³ -benzoylthymine under Mitsunobu conditions afforded N-Boc-L-α-amino-γ-N³ -benzoylthymine butyric acid benzylester. After removal of the N-benzoyl and O-benzyl protecting group, this compound was used in solution phase peptide synthesis.

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Peptide Analogues of DNA Consisting of l-α-Amino-γ-thymine Butyric Acid and l-Valine Subunits

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Peptide Analogues of DNA Consisting of l-α-Amino-γ-thymine Butyric Acid and l-Valine Subunits

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