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III. OLIGONUCLEOTIDES: Chemistry

Studies on Reactions of Nucleoside H-Phosphonates with Bifunctional Reagents. Part III. Further Studies on Transesterification of Nucleoside H-Phosphonate Diesters with Amino Alcohols

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Pages 839-842 | Published online: 16 Feb 2007
 

Abstract

Reactions of 5′-O-(4,4′-dimethoxytrityl)thymidin-3′-yl 2-cyanoethyl phosphonate with alcohols, amines and amino alcohols in pyridine are described Transesterification was found to be faster than β-elimination of 2-cyanoethyl group

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