Solid Phase Synthesis of 5′-Methylenephosphonate DNA

Tomas Szabó Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91, Stockholm, Sweden

Annika Kers Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91, Stockholm, Sweden

Jacek Stawinski Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91, Stockholm, Sweden

Abstract

A new approach to the solid phase synthesis of 5′-methylenephosphonate DNA is described. It makes use of intramolecular catalysis which ensures rapid and high-yielding condensations and thus provides a convenient entry to ionic, achiral analogs of thymidylic acids up to 20 nucleotides in length.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Solid Phase Synthesis of 5′-Methylenephosphonate DNA

Information for

Open access

Opportunities

Help and information

Solid Phase Synthesis of 5′-Methylenephosphonate DNA

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature