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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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III. OLIGONUCLEOTIDES: Chemistry

Oligodeoxyribonucleotides Covalently Linked via Nucleic Bases with 3′-5′ and 5′-5′ Polarities

Ulysse Asseline Centre de Biophysique Moléculaire, CNRS, Rue Charles Sadron, 45071, Orléans Cedex, 2, France
&
N. T. Thuong Centre de Biophysique Moléculaire, CNRS, Rue Charles Sadron, 45071, Orléans Cedex, 2, France
Pages 889-893 | Published online: 16 Feb 2007
 
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Abstract

The solid-phase preparation of oligodeoxyribonucleotides covalently linked via nucleic bases with normal (3′-5′) or inverted (5′-5′) polarities is reported. The key-step of these syntheses is the preparation of the tethered dimers.

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