Synthesis of the 3′-Derivatives of Phosphorothioate Oligonucleotide Analogues

N. V. Amirkhanov Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, 630090, Russia

V. F. Zarytova Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, 630090, Russia

Abstract

3′-Derivatives of phosphorothioate (PS) oligonucleotide analogues have been synthesized by a selective activation of a 3′-terminal phosphate group of the deprotected PS oligonucleotides using a mixture of triphenylphosphine and 2,2′-dipyridyldisulfide.

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Synthesis of the 3′-Derivatives of Phosphorothioate Oligonucleotide Analogues

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Synthesis of the 3′-Derivatives of Phosphorothioate Oligonucleotide Analogues

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