Approaches to Enhance the Binding Affinity and Nuclease Stability of Triplex Forming Oligonucleotides

K. Jayaraman Triplex Pharmaceutical Corporation, 9391 Grogans Mill Road, The Woodlands, TX, 77380, U.S.A.

R. H. Durland Triplex Pharmaceutical Corporation, 9391 Grogans Mill Road, The Woodlands, TX, 77380, U.S.A.

T. S. Rao Triplex Pharmaceutical Corporation, 9391 Grogans Mill Road, The Woodlands, TX, 77380, U.S.A.

G. R. Revankar Triplex Pharmaceutical Corporation, 9391 Grogans Mill Road, The Woodlands, TX, 77380, U.S.A.

V. Bodepudi Triplex Pharmaceutical Corporation, 9391 Grogans Mill Road, The Woodlands, TX, 77380, U.S.A.

N. Chaudhary Triplex Pharmaceutical Corporation, 9391 Grogans Mill Road, The Woodlands, TX, 77380, U.S.A.

J. Guy-Caffey Triplex Pharmaceutical Corporation, 9391 Grogans Mill Road, The Woodlands, TX, 77380, U.S.A.

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Abstract

The ability of simple azole nucleosides to promote antiparallel triplex formation at non-homopurine duplex targets was explored. It was also shown that spermidine-cholesterol conjugation is effective in enhancing cellular uptake and stability of oligonucleotides.

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Approaches to Enhance the Binding Affinity and Nuclease Stability of Triplex Forming Oligonucleotides

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Approaches to Enhance the Binding Affinity and Nuclease Stability of Triplex Forming Oligonucleotides

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