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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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III. OLIGONUCLEOTIDES: Biophysics/Biochemistry

Hoogsteen-Duplex DNA: Synthesis and Base Pairing of Oligodeoxynucleotides Containing 1-Deaza-2′-deoxyadenosine

Frank Seela Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Barbarastr., 7, D-49069, Osnabrück, Germany
,
Thomas Wenzel Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Barbarastr., 7, D-49069, Osnabrück, Germany
&
Harald Debelak Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Barbarastr., 7, D-49069, Osnabrück, Germany
Pages 957-960 | Published online: 16 Feb 2007
 
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Abstract

Solid-phase synthesis of oligonucleotides containing 1-deazaadenine was carried out employing phosphonate and phosphoramidite chemistry. Hoogsteen base pairing was established for the duplex d(c1A20)·d(T20).

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