Triple Helix Forming α-Oligonucleotides Containing 5-Methylcytosine and/or 5-Bromouracil

Francęois Morvan Laboratoire de Chimie Bio-Organique, URA 488 du CNRS, Université de Montpellier II, Place E. Bataillon, 34095, Montpellier cedex, 5, France

Carole Chaix Laboratoire de Chimie Bio-Organique, URA 488 du CNRS, Université de Montpellier II, Place E. Bataillon, 34095, Montpellier cedex, 5, France

Axel Zeissler Laboratoire de Chimie Bio-Organique, URA 488 du CNRS, Université de Montpellier II, Place E. Bataillon, 34095, Montpellier cedex, 5, France

Bernard Rayner Laboratoire de Chimie Bio-Organique, URA 488 du CNRS, Université de Montpellier II, Place E. Bataillon, 34095, Montpellier cedex, 5, France

Jean-Louis Imbach Laboratoire de Chimie Bio-Organique, URA 488 du CNRS, Université de Montpellier II, Place E. Bataillon, 34095, Montpellier cedex, 5, France

Abstract

Stability of αββ triplexes constituted with an α-strand containing 5-methylcytosine and/or 5-bromouracil was studied at a wide pH range. Introduction of 5-methylcytosine increases hybridization stability of the triplexes while introduction 5-broumouracil does not change it.

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Triple Helix Forming α-Oligonucleotides Containing 5-Methylcytosine and/or 5-Bromouracil

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Triple Helix Forming α-Oligonucleotides Containing 5-Methylcytosine and/or 5-Bromouracil

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