Postsynthetic Transformations of Oligodeoxynucleotides Originated at 6-Methylthio-purine Site

Artur Burdzy Faculty of Chemistry, Adam Mickiewicz University, Poznań

Bohdan Skalski Faculty of Chemistry, Adam Mickiewicz University, Poznań

Ewa Biał Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland

Andrzej Kowalewski Faculty of Chemistry, Adam Mickiewicz University, Poznań

Stefan Paszyc Faculty of Chemistry, Adam Mickiewicz University, Poznań

Rys2ard W. Adamiak Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland

Abstract

New route to oligodeoxynucleotides labeled with fluorescent luminarine was explored. Regioselective oxidation of 6-methylthio-purines to 6-methylsulphoxides reactive toward pyridine was achieved. Upon UV irradiation of 6-pyridinium-purines oligonucleotide cleavage instead of phototransformation to luminarine was observed.

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Postsynthetic Transformations of Oligodeoxynucleotides Originated at 6-Methylthio-purine Site

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Postsynthetic Transformations of Oligodeoxynucleotides Originated at 6-Methylthio-purine Site

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