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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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III. OLIGONUCLEOTIDES: Biophysics/Biochemistry

Enzymatic Synthesis of Stereoregular (All Rp) Oligonucleotide Phosphorothioate and Its Properties

Jinyan Tang Hybridon, Inc., One Innovation Drive, Worcester, MA, 01545
,
Allysen Roskey Hybridon, Inc., One Innovation Drive, Worcester, MA, 01545
,
Ying Li Hybridon, Inc., One Innovation Drive, Worcester, MA, 01545
&
Sudhir Agrawal Hybridon, Inc., One Innovation Drive, Worcester, MA, 01545
Pages 985-990 | Published online: 16 Feb 2007
 
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Abstract

A protocol has been established for the synthesis of stereoregular (all Rp) oligonucleotide phosphorothioates. A 25-mer oligodeoxynucleotide phosphorothioate has been synthesized and studied for biophysical and biochemical properties.

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