Synthesis and Properties of Oligonucleotide (2-Aminoethyl)Phosphonates

Alan F. Cook PharmaGenics, Inc., 4 Pearl Court, Allendale, New Jersey, 07401, USA

Reza Fathi PharmaGenics, Inc., 4 Pearl Court, Allendale, New Jersey, 07401, USA

Qing Huang PharmaGenics, Inc., 4 Pearl Court, Allendale, New Jersey, 07401, USA

George Coppola PharmaGenics, Inc., 4 Pearl Court, Allendale, New Jersey, 07401, USA

William Delaney PharmaGenics, Inc., 4 Pearl Court, Allendale, New Jersey, 07401, USA

Jia-Lin Syi PharmaGenics, Inc., 4 Pearl Court, Allendale, New Jersey, 07401, USA

Abstract

Oligonucleotides with novel, cationic backbone substituents have been prepared. Dinucleotide aminoethylphosphonates have been synthesized and the isomers were separated and used to prepare oligonucleotides with alternating positive and negative charges. The properties of these oligonucleotides have been examined.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Synthesis and Properties of Oligonucleotide (2-Aminoethyl)Phosphonates

Information for

Open access

Opportunities

Help and information

Synthesis and Properties of Oligonucleotide (2-Aminoethyl)Phosphonates

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature