Optimization of Antisense Chimeric Oligonucleotides Containing α- and β-Anomeric Deoxynucleotides

F. Debart Laboratoire de Chimie Bio-organique, URA 488 CNRS, Case 008, Université Montpellier II, Place Eugène Bataillon, 34095, Montpellier Cedex, 5, France

G. Tosquellas Laboratoire de Chimie Bio-organique, URA 488 CNRS, Case 008, Université Montpellier II, Place Eugène Bataillon, 34095, Montpellier Cedex, 5, France

B. Rayner Laboratoire de Chimie Bio-organique, URA 488 CNRS, Case 008, Université Montpellier II, Place Eugène Bataillon, 34095, Montpellier Cedex, 5, France

J.-L. Imbach Laboratoire de Chimie Bio-organique, URA 488 CNRS, Case 008, Université Montpellier II, Place Eugène Bataillon, 34095, Montpellier Cedex, 5, France

Abstract

Various chimeric oligonucleotides containing α- and β-anomeric deoxynucleotide units and directed against the splice acceptor site of the HIV-1 tat RNA have been synthesized. Their hybridizing abilities to complementary DNA or RNA single strands, and their stability in cell culture medium or cell extracts were studied.

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Optimization of Antisense Chimeric Oligonucleotides Containing α- and β-Anomeric Deoxynucleotides

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Optimization of Antisense Chimeric Oligonucleotides Containing α- and β-Anomeric Deoxynucleotides

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