Synthesis and Properties of 2′-O-Methylribonucleotide Methylphosphonate Containing Chimeric Oligonucleotides

Ekambar R. Kandimalla Hybridon, Inc., One Innovation Drive, Worcester, MA, 01605, USA

Jamal Temsamani Hybridon, Inc., One Innovation Drive, Worcester, MA, 01605, USA

Sudhir Agrawal Hybridon, Inc., One Innovation Drive, Worcester, MA, 01605, USA

Abstract

2′-O-methylribonucleoside methylphosphonamidites are synthesized and incorporated into oligonucleotides to obtain chimeric antisense oligonucleotides. The resulting oligonucleotide binds to their target RNA/DNA sequences efficiently and stable in a medium containing bovine serum.

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Synthesis and Properties of 2′-O-Methylribonucleotide Methylphosphonate Containing Chimeric Oligonucleotides

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Synthesis and Properties of 2′-O-Methylribonucleotide Methylphosphonate Containing Chimeric Oligonucleotides

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