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III. OLIGONUCLEOTIDES: Biophysics/Biochemistry

Xylose-DNA: Sequence-Dependent Duplex Stability as Function of Backbone Configuration

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Pages 1041-1045 | Published online: 16 Feb 2007
 

Abstract

The base pairing of a series of homooligomeric or telomeric oligonucleotides built-up from 2′-deoxy-β]-D-xyloadenosine and/or -thymidine were synthesized and studied with respect to their thermodynamics of duplex formation. Oligo (2′-deoxyxylonucleotides) are more stable than the corresponding regular oligomers the more d(xA-xT) elements they contain.

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