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Nucleosides and Nucleotides Volume 14, 1995 - Issue 3-5
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III. OLIGONUCLEOTIDES: Biophysics/Biochemistry

To Wobble or Not to Wobble: Modified Bases Incorporated into DNA

L. Van Meervelt Chemistry Department, K. U. Leuven, Celestijnenlaan 200F, B-3001, Leuven, Belgium
,
M. H. Moore Chemistry Department, York University, Heslington York YO15DD, UK
,
P. K. T. Lin The Robert Gordon University, St. Andrew Street, Aberdeen, AB1 1HG, UK
&
D. M. Brown MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
Pages 1057-1059 | Published online: 16 Feb 2007
 
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Abstract

The ambivalent base analogue P was incorporated in the d(CGCGPG) hexamer to investigate the G.P base pair geometry by X-ray diffraction. Both Watson-Crick and wobble geometries have been found for the crystallographic independent G.P base pairs.

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