New Photoreactive mRNA Analogues for the Affinity Labeling of Ribosomes

A. G. Venyaminova Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, 630090, Russia

M. N. Repkova Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, 630090, Russia

T. M. Ivanova Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, 630090, Russia

M. I. Dobrikov Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, 630090, Russia

K. N. Bulygin Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, 630090, Russia

D. M. Graifer Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, 630090, Russia

G. G. Karpova Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, 630090, Russia

V. F. Zarytova Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, 630090, Russia

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Abstract

Chemical synthesis of the model mRNA analogues (AUGU₃, (pU)_n) bearing p-azidotetrafluorobenzamido, p-azidobenzamido or 2-nitro-5-azidobenzamido groups coupled to the 5′-terminal phosphate or to the C-8-position of adenosine is described. The first results of the photoaffinity labeling study of human placenta ribosomes are presented.

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New Photoreactive mRNA Analogues for the Affinity Labeling of Ribosomes

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New Photoreactive mRNA Analogues for the Affinity Labeling of Ribosomes

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