Synthesis and Use of (2′,5′)Oligoadenylate Trimers Modified at the 2′-Terminus in Kidney Transplantation in Rabbits and Monkeys

I. A. Mikhailopulo Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, 220141, Minsk, Byelorussia

Z. Yu. Tkachuk Institute of Molecular Biology and Genetics, Ukrainian Academy of Sciences, 252143, Kiev, Ukraine

E. A. Baran Institute of Molecular Biology and Genetics, Ukrainian Academy of Sciences, 252143, Kiev, Ukraine

L. V. Tkachuk Institute of Molecular Biology and Genetics, Ukrainian Academy of Sciences, 252143, Kiev, Ukraine

A. V. Koslov Institute of Molecular Biology and Genetics, Ukrainian Academy of Sciences, 252143, Kiev, Ukraine

I. I. Slukvin Institute of Molecular Biology and Genetics, Ukrainian Academy of Sciences, 252143, Kiev, Ukraine

E. I. Kvasyuk Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, 220141, Minsk, Byelorussia

T. I. Kulak Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, 220141, Minsk, Byelorussia

G. Kh. Matsuka Institute of Molecular Biology and Genetics, Ukrainian Academy of Sciences, 252143, Kiev, Ukraine

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Abstract

Two core trimers, (2′,5′)A₂A_RA and (2′,5′)A₂A^LA, with 9-(2,3-anhydro-β]-D-ribofuranosyl)adenine (A_RA) and its lyxo-isomer (A^LA) at the 2′(3′)-terminus, respectively, were synthesized and their use as immunosuppressors in kidney transplantation in animals was investigated.

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Synthesis and Use of (2′,5′)Oligoadenylate Trimers Modified at the 2′-Terminus in Kidney Transplantation in Rabbits and Monkeys

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Synthesis and Use of (2′,5′)Oligoadenylate Trimers Modified at the 2′-Terminus in Kidney Transplantation in Rabbits and Monkeys

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