![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
Bisphenol A (BPA) is an industrial chemical with estrogenic activity. In our study, 40 rats were given BPA at 4, 40, and 400 mg/kg per day. Controls were treated with corn oil of same volume until the offspring were 30 d olds. At the end of the experiment, the expression of estrogen receptor (ER)-α and the mRNA levels of inerleukin (IL)-2, IL-12, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α in spleens were investigated by Western blotting and real-time reverse-transcription polymerase chain reaction (RT-PCR). The histopathological change of organs was observed. The results showed that bisphenol A reduced the expression of ER-α in males of the high-dose group in the F0 generation and in middle- and high-dose groups of the F1 generation (p < .05), but increased it in females in the high-dose group of the F0 generation and in middle- and high-dose groups of the F1 generation (p < .05). The levels of IL-2, IL-12, IFN-γ, and TNF-α in spleens were downregulated in all groups in contrast to controls (p < .05). We also found some histological changes in spleens, livers, and kidneys. These findings demonstrated that bisphenol A has estrogen-like activity and might affect some immune organs and parameters.
Acknowledgements
This work was supported by the Institute of Hygiene and Environmental Medicine. We thank Dr. Z. Gao for the funding of the experiment and the Center of Disease Control and Prevention of Shandong for the use of the ABI 7300.
