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Original Articles

Toward a Mechanism of Prion Misfolding and Structural Models of PrPSc: Current Knowledge and Future Directions

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Pages 154-160 | Published online: 06 Jan 2011
 

Abstract

Despite extensive investigation, many features of prion protein misfolding remain enigmatic. Physicochemical variables known to influence misfolding are reviewed to help elucidate the mechanism of prionogenesis and identify salient features of PrPSc, the misfolded conformer of the prion protein. Prospective work on refinement of candidate PrPSc models based on thermodynamic considerations will help to complete atomic-scale structural details missing from experimental studies and may explain the basis for the templating activity of PrPSc in disease.

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