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Journal of Toxicology and Environmental Health, Part A
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Volume 79, 2016 - Issue 1
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Original Articles

Impaired brain StAR and HSP70 gene expression in zebrafish exposed to Methyl-Parathion based insecticide

João Gabriel Santos da RosaPrograma de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, BrazilView further author information
,
Gessi KoakoskiPrograma de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, BrazilView further author information
,
Angelo L. PiatoPrograma de Pós-Graduação em Farmacologia e Terapêutica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, BrazilView further author information
,
Maurício Reis BogoPrograma de Pós-Graduação em Biologia Celular e Molecular, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, BrazilView further author information
,
Carla Denise BonanPrograma de Pós-Graduação em Biologia Celular e Molecular, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, BrazilView further author information
&
Leonardo José Gil BarcellosPrograma de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil;Universidade de Passo Fundo (UPF), Campus Universitário do Bairro São José, Passo Fundo, Rio Grande do Sul, Brazil;Programa de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo (UPF), Campus Universitário do Bairro São José, Passo Fundo, Rio Grande do Sul, BrazilCorrespondence[email protected]
View further author information
Pages 1-7 | Received 28 May 2015, Accepted 20 Sep 2015, Published online: 23 Dec 2015
 
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ABSTRACT

Fish production ponds and natural water body areas located in close proximity to agricultural fields receive water with variable amounts of agrochemicals, and consequently, compounds that produce adverse effects may reach nontarget organisms. The aim of this study was to investigate whether waterborne methyl-parathion-based insecticide (MPBI) affected gene expression patterns of brain glucocorticoid receptor (GR), steroidogenic acute regulatory protein (StAR), and heat shock protein 70 (hsp70) in adult zebrafish (Danio rerio) exposed to this chemical for 96 h. Treated fish exposed to MPBI-contaminated water showed an inhibition of brain StAR and hsp70 gene expression. Data demonstrated that MPBI produced a decrease brain StAR and hsp70 gene expression.

Additional information

Funding

Leonardo José Gil Barcellos has a CNPq research fellowship (301992/2014-2).

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