Toxicity and occupational exposure assessment for Fischer-Tropsch synthetic paraffinic kerosene

ABSTRACT

Fischer-Tropsch (FT) Synthetic Paraffinic Kerosene (SPK) jet fuel is a synthetic organic mixture intended to augment petroleum-derived JP-8 jet fuel use by the U.S. armed forces. The FT SPK testing program goal was to develop a comparative toxicity database with petroleum-derived jet fuels that may be used to calculate an occupational exposure limit (OEL). Toxicity investigations included the dermal irritation test (FT vs. JP-8 vs. 50:50 blend), 2 in vitro genotoxicity tests, acute inhalation study, short-term (2-week) inhalation range finder study with measurement of bone marrow micronuclei, 90-day inhalation toxicity, and sensory irritation assay. Dermal irritation was slight to moderate. All genotoxicity studies were negative. An acute inhalation study with F344 rats exposed at 2000 mg/m³ for 4 hr resulted in no abnormal clinical observations. Based on a 2-week range-finder, F344 rats were exposed for 6 hr per day, 5 days per week, for 90 days to an aerosol-vapor mixture of FT SPK jet fuel (0, 200, 700 or 2000 mg/m³). Effects on the nasal cavities were minimal (700 mg/m³) to mild (2000 mg/m³); only high exposure produced multifocal inflammatory cell infiltration in rat lungs (both genders). The RD₅₀ (50% respiratory rate depression) value for the sensory irritation assay, calculated to be 10,939 mg/m^3, indicated the FT SPK fuel is less irritating than JP-8. Based upon the proposed use as a 50:50 blend with JP-8, a FT SPK jet fuel OEL is recommended at 200 mg/m³ vapor and 5 mg/m³ aerosol, in concurrence with the current JP-8 OEL.

Acknowledgments

The toxicity program sponsor was the Alternative Fuels Certification Office (AFCO), Wright-Patterson AFB OH. This research was performed in compliance with DODI 3216.1. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the U.S. Air Force, U.S. Army, the Department of the Navy, Department of Defense, nor the U.S. Government. This work was prepared as part of official duties by employees of the U.S. Government. Title 17, U.S.C. §105 provides that copyright protection under this title is not available for any work of the U.S. Government.