Detection by alkaline elution of rat liver DNA damage induced by simultaneous subacute administration of nitrite and aminopyrine

S. Parodi Department of Oncology, University of Genoa, Genoa, 1–16132, Italy

M. Taningher Department of Oncology, University of Genoa, Genoa, 1–16132, Italy

M. Pala Department of Oncology, University of Genoa, Genoa, 1–16132, Italy

G. Brambilla Department of Pharmacology, University of Genoa, Genoa, I‐16132, Italy; Istituto di Farmacologia dell'Università, Viale Benedetto XV, 2, Genova, I‐16132, Italy

M. Cavanna Department of Pharmacology, University of Genoa, Genoa, I‐16132, Italy

Abstract

DNA fragmentation induced in the livers of rats by oral treatment with NaNO₂ and aminopyrine was evaluated by the alkaline elution technique. Whereas simultaneous administration of the two compounds in a single dose produced only a minimal increase of the DNA elution rate, their intake with drinking water for 20 successive days caused DNA fragmentation comparable to that observed after a single ip injection of 10–20 mg/kg N‐nitrosodimethylamine. Either NaNO₂ or aminopyrine alone induced borderline DNA damaging effects, if any, in both rats receiving a single dose and those treated for 20 successive days.

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Detection by alkaline elution of rat liver DNA damage induced by simultaneous subacute administration of nitrite and aminopyrine

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Detection by alkaline elution of rat liver DNA damage induced by simultaneous subacute administration of nitrite and aminopyrine

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