Advanced search
Publication Cover
Journal of Toxicology and Environmental Health Volume 6, 1980 - Issue 5-6: Occupational cancer and carcinogenesis
Journal homepage
4
Views
1
CrossRef citations to date
0
Altmetric
Part one: Current aspects of cancer etiology

Radiation carcinogenesis

Jorma Rantanen Institute of Occupational Health, Helsinki, Finland
Pages 971-976 | Published online: 20 Oct 2009
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

In radiation‐induced carcinogenesis the stages of initiation, transformation, and promotion can be identified. Radiation carcinogenesis is a stochastic phenomenon that does not exhibit any threshold in the dose‐response relationship. The most important risk to be controlled is that of the population‐either industrial or medical‐exposed to radiation at low levels and low dose rates. Despite the expanding use of radiation, the average doses in most industrialized societies have not been increasing during the last few years. However, sensitive subpopulations with high cancer risks are included within the present low‐level average exposure figures.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Genomic Instability Induced by Ionizing Radiation
Source: JSTOR
Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells.
Source: Proceedings of the National Academy of Sciences
Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect.
Source: JSTOR
Studies of the Mortality of Atomic Bomb Survivors.Report 12, Part I. Cancer: 1950–1990
Source: JSTOR
Inflammatory-type responses after exposure to ionizing radiation in vivo : a mechanism for radiation-induced bystander effects?
Source: Springer Science and Business Media LLC
Increased chromosome aberration levels in cells from mouse fetuses after zygote X-irradiation.
Source: Informa UK Limited
Relationship between x-ray exposure and malignant transformation in C3H 10T1/2 cells.
Source: Proceedings of the National Academy of Sciences
Effect of Confluent Holding on Potentially Lethal Damage Repair, Cell Cycle Progression, and Chromosomal Aberrations in Human Normal and Ataxia-Telangiectasia Fibroblasts
Source: JSTOR
Contrasting roles for C/EBPα and notch in irradiation-induced multipotent hematopoietic progenitor cell defects
Source: Wiley
Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes : Evidence for release during irradiation of a signal controlling survival into the medium
Source: JSTOR
Timing of the steps in transformation of C3H 10T½ cells by X-irradiation
Source: Springer Science and Business Media LLC
Defective Transcription-Coupled Repair of Oxidative Base Damage in Cockayne Syndrome Patients from XP Group G
Source: American Association for the Advancement of Science (AAAS)
Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles.
Source: JSTOR
Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene.
Source: Wiley
The nature of mutants induced by ionising radiation in cultured hamster cells III. Molecular characterization of HPRT-deficient mutants induced by γ-rays or α-particles showing that the majority have deletions of all or part of the hprt gene
Source: Elsevier BV
Mutational landscape of T-cell lymphoma in mice lacking the DNA mismatch repair gene Mlh1: no synergism with ionizing radiation.
Source: Oxford University Press
Delayed chromosomal instability induced by DNA damage
Source: American Society for Microbiology
Toxicity and mutagenicity of X-rays and [125I]dUrd or [3H]TdR incorporated in the DNA of human lymphoblast cells.
Source: Elsevier BV
Parasagittal cranial fasciitis after irradiation of a cerebellar medulloblastoma: case report.
Source: Oxford University Press (OUP)
ALTERATIONS OF MDM2 GENE IN X-RAY TRANSFORMED MOUSE 10T1/2 CELL CLONES
Source: Spandidos Publications
Critical target and dose and dose-rate responses for the induction of chromosomal instability by ionizing radiation.
Source: JSTOR
Malignant transformation induced by incorporated radionuclides in BALB/3T3 mouse embryo fibroblasts.
Source: Proceedings of the National Academy of Sciences
Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells
Source: Informa UK Limited
In vivo formation and repair of DNA double-strand breaks after computed tomography examinations
Source: Proceedings of the National Academy of Sciences
Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype.
Source: Elsevier BV
X rays induce interallelic homologous recombination at the human thymidine kinase gene.
Source: American Society for Microbiology
The C Terminus of Ku80 Activates the DNA-Dependent Protein Kinase Catalytic Subunit
Source: American Society for Microbiology
A mini-review on mechanochemical treatment of contaminated soil: From laboratory to large-scale
Source: Informa UK Limited
Genetic and epigenetic changes in chromosomally stable and unstable progeny of irradiated cells.
Source: Public Library of Science (PLoS)
Changing Views of Cellular Radiosensitivity
Source: JSTOR
TheRAD52epistasis group in mammalian double strand break repair
Source: Elsevier BV
Initial events in the cellular effects of ionizing radiations: clustered damage in DNA.
Source: Informa UK Limited
Chromosomal instability
Source: Springer Science and Business Media LLC
Clonal chromosome aberrations and genomic instability in X-irradiated human T-lymphocyte cultures
Source: Elsevier BV
Microsatellite instability in thorotrast-induced human intrahepatic cholangiocarcinoma.
Source: Wiley
Mouse Models for Efficacy Testing of Agents against Radiation Carcinogenesis—A Literature Review
Source: MDPI AG
Alpha-particle-induced sister chromatid exchange in normal human lung fibroblasts: evidence for an extranuclear target.
Source: JSTOR
Rodent 2-year cancer bioassays and in vitro and in vivo genotoxicity tests insufficiently predict risk or model development of human carcinomas:
Source: SAGE Publications
Radiation Dose and Sarcoma Risk
Source: American Medical Association (AMA)
Radiation mutagenesis: the initial DNA lesions responsible.
Source: JSTOR
Deregulated DNA polymerase β strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities
Source: Springer Science and Business Media LLC
Responses to low doses of ionizing radiation in biological systems.
Source: SAGE Publications
Cell cycle control and cancer
Source: American Association for the Advancement of Science (AAAS)
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
Source: Cold Spring Harbor Laboratory
Delayed Reproductive Death in X-irradiated Chinese Hamster Ovary Cells
Source: Informa UK Limited
Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know
Source: Proceedings of the National Academy of Sciences
Cell cycle regulation in response to DNA damage in mammalian cells: a historical perspective.
Source: Springer Science and Business Media LLC
Second malignant neoplasms and cardiovascular disease following radiotherapy.
Source: Ovid Technologies (Wolters Kluwer Health)
Chromosomal Instability in the Descendants of Unirradiated Surviving Cells after α -Particle Irradiation
Source: Proceedings of the National Academy of Sciences
Radioprotective effects of Zingiber officinale Roscoe (ginger): past, present and future.
Source: Royal Society of Chemistry (RSC)
Tissue responses in radiation pathology
Source: Wiley
Targeted cytoplasmic irradiation induces bystander responses.
Source: Proceedings of the National Academy of Sciences
Mutagenic effects of a single and an exact number of alpha particles in mammalian cells
Source: Proceedings of the National Academy of Sciences
Review and evaluation of updated research on the health effects associated with low-dose ionising radiation
Source: Oxford University Press (OUP)
Alpha particles induce the production of interleukin-8 by human cells.
Source: JSTOR
Radiation-induced genomic instability: delayed mutagenic and cytogenetic effects of X rays and alpha particles.
Source: JSTOR
Transmission of chromosomal instability after plutonium α-particle irradiation
Source: Springer Science and Business Media LLC
EFFECT OF CATION RADICAL FORMATION ON REACTIVITY AND ACIDITY ENHANCEMENT OF CYTOSINE NUCLEOBASE: NATURAL BOND ORBITAL AND ATOM IN MOLECULE ANALYSIS
Source: World Scientific Pub Co Pte Lt

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.