![Sample our Engineering & Technology journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5933/TOC-Subject-Sample-2021-Engineering-Tech.jpg"})
Abstract
The spermatogenic cell sensitivity in the induction of sperm abnormalities by two antineoplastic agents, thio‐TEPA and hydroxyurea in inbred Lakeview hamsters was studied and the results were compared with those of similar investigations with mice. Testis weights, epididymal sperm numbers, and body weights were also monitored up to 12 wk after treatment. Thio‐TEPA administration increased sperm abnormalities and reduced testis weights as well as sperm numbers in a dose‐dependent manner at wk 4 and 12 after treatment. Hydroxyurea administration was ineffective in inducing sperm abnormalities, but testis weights and sperm numbers were adversely affected. Dose‐dependent changes in body weights after treatment with either agent were also recorded. The findings with thio‐TEPA on sperm morphology agree with those reported for the mouse. However, unlike the results of the mouse studies, hydroxyurea effects on sperm shape were not observed in the hamster.
