Natural history of TCDD‐induced liver lesions in rats as observed by transmission electron microscopy during a 32‐week period after a single intraperitoneal injection

G. Weber Institute of Pathological Anatomy, University of Siena, Italy; Istituto di Anatomia Patologica, Via delle Scotte, Siena, 53100, Italy

P. Luzi Institute of Pathological Anatomy, University of Siena, Italy

L. Resi Institute of Pathological Anatomy, University of Siena, Italy

P. Tanganelli Institute of Pathological Anatomy, University of Siena, Italy

M. R. Lovati Institute of Pharmacology and Pharmacognosy, University of Milan, Italy

A. Poli Institute of Pharmacology and Pharmacognosy, University of Milan, Italy

Abstract

Forty‐two male rats were injected with a single intraperitoneal dose of TCDD in acetone and corn oil and sacrificed after 2, 4, 8, 16, 24, and 32 weeks, to study the long‐term effects of a single injection. The liver lesions become progressively worse up to the 16th week and appear thereafter to slowly regress.

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Natural history of TCDD‐induced liver lesions in rats as observed by transmission electron microscopy during a 32‐week period after a single intraperitoneal injection

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Natural history of TCDD‐induced liver lesions in rats as observed by transmission electron microscopy during a 32‐week period after a single intraperitoneal injection

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