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Journal of Toxicology and Environmental Health Volume 17, 1986 - Issue 2-3: Inhalation and Pulmonary Toxicology
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Original Articles

Early alveolar clearance in rabbits intermittently exposed to sulfuric acid mist

Richard B. Schlesinger Institute of Environmental Medicine, New York University Medical Center, 550 First Ave., New York, New York, 10016
&
Jeffery M. Gearhart Institute of Environmental Medicine, New York University Medical Center, New York, New York
Pages 213-220 | Received 12 Jun 1985, Accepted 30 Jul 1985, Published online: 20 Oct 2009
 
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Abstract

During the course of 1‐h/d, 5‐dlwk exposure to submicrometer sulfuric acid mist at 250 μg/m3, rabbits were exposed to a radioactively tagged polystyrene latex tracer aerosol to assess clearance from the alveolar region during the period 2–14 d after tracer exposure. The latex was administered on d 1, 57, and 240 following the start of the H2SO4 exposures. Early alveolar clearance was found to be accelerated during the first test, and this acceleration was maintained throughout the 8‐mo monitoring period.

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