Evaluation of the chronic inhalation toxicity of a manganese oxide aerosol. II - Clinical observations, hematology, clinical chemistry and histopathology

Abstract

Monkeys and rats were exposed to 11.6,112.5, or 1152 µg Mn/m³ as an Mn₃O₄ aerosol twenty-four hours per day for nine months. Various serum biochemical, and hematologic evaluations were conducted on both specie. Body weight gain was accelerated in rats exposed to 1152 µg Mn/m³. Hemoglobin concentrations were slightly elevated for both sexes and both specie exposed to 1152 µg Mn/m³; however, the effect may not be directly related to Mn. Some evidence of hypophosphatemia was observed. No exposure related effects were demonstrated by organ weight or histopathologic observations.